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Safety and Side Effects Orforglipron brought mostly mild or moderate gastrointestinal symptoms

10.3945/jn.109.119024 49 GlinI.EliasR.GepdiremenA.CheaA.TopalF

Evidence from preclinical and clinical studies suggests heterogeneous effects of GLP1RAs on cancer risk: the incidence of hepatocellular, oesophageal, endometrial, ovarian and prostate cancers might be reduced, whereas safety concerns persist with respect to thyroid (both medullary and non-medullary) carcinomas